No Association Between Apoε4 Alleles, HIV Infection, Age, Neuropsychological Outcome or Death
Identifieur interne : 001E72 ( Main/Exploration ); précédent : 001E71; suivant : 001E73No Association Between Apoε4 Alleles, HIV Infection, Age, Neuropsychological Outcome or Death
Auteurs : James T. Becker [États-Unis] ; Jeremy J. Martinson [États-Unis] ; Sudhir Penugonda ; Lawrence Kingsley [États-Unis] ; Samantha Molsberry [États-Unis] ; Steven Wolinsky ; Sandra Reynolds ; Aaron Aronow [États-Unis] ; Karl Goodkin ; Andrew Levine ; Eileen Martin ; Eric N. Miller ; Cynthia A. Munro ; Ann Ragin ; Ned SacktorSource :
- Journal of neurovirology [ 1355-0284 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Allèles, Analyse de survie, Apolipoprotéine E4 (génétique), Cognition, Dysfonctionnement cognitif (mortalité), Dysfonctionnement cognitif (psychologie), Dysfonctionnement cognitif (virologie), Dysfonctionnement cognitif (étiologie), Expression des gènes, Facteurs de l'âge, Génotype, Homosexualité masculine, Humains, Infections à VIH (), Infections à VIH (mortalité), Infections à VIH (psychologie), Infections à VIH (virologie), Mâle, Niveau d'instruction, Populations d'origine continentale, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests neuropsychologiques, Études prospectives.
- MESH :
- génétique : Apolipoprotéine E4.
- mortalité : Dysfonctionnement cognitif, Infections à VIH.
- psychologie : Dysfonctionnement cognitif, Infections à VIH.
- virologie : Dysfonctionnement cognitif, Infections à VIH.
- étiologie : Dysfonctionnement cognitif.
- Adulte, Adulte d'âge moyen, Allèles, Analyse de survie, Cognition, Expression des gènes, Facteurs de l'âge, Génotype, Homosexualité masculine, Humains, Infections à VIH, Mâle, Niveau d'instruction, Populations d'origine continentale, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests neuropsychologiques, Études prospectives.
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Alleles, Apolipoprotein E4 (genetics), Cognition, Cognitive Dysfunction (etiology), Cognitive Dysfunction (mortality), Cognitive Dysfunction (psychology), Cognitive Dysfunction (virology), Continental Population Groups, Educational Status, Gene Expression, Genotype, HIV Infections (complications), HIV Infections (mortality), HIV Infections (psychology), HIV Infections (virology), Homosexuality, Male, Humans, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Survival Analysis.
- MESH :
- chemical , genetics : Apolipoprotein E4.
- complications : HIV Infections.
- etiology : Cognitive Dysfunction.
- mortality : Cognitive Dysfunction, HIV Infections.
- psychology : Cognitive Dysfunction, HIV Infections.
- virology : Cognitive Dysfunction, HIV Infections.
- Adult, Age Factors, Aged, Aged, 80 and over, Alleles, Cognition, Continental Population Groups, Educational Status, Gene Expression, Genotype, Homosexuality, Male, Humans, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Survival Analysis.
Abstract
The ε4 allele of the ApoE gene may have important interactions with physical health and cognitive function among individuals with HIV disease. The purpose of this study is to examine the relationships between ε4, HIV disease, age, neuropsychological impairment and death in a large, well-characterized study sample. 2,846 men participating in the Multicenter AIDS Cohort Study had ApoE genotyping and neuropsychological test data available for analysis. We found a significant association between HIV infection and time to death (from any cause), as well as older age, race, and education. But, ApoE status was not significantly associated with time to death. Similarly, we found a significant association between HIV infection and time to incident cognitive impairment, as well as age, education, and HIV serostatus; Apoε4 status was not related to incident cognitive impairment. There were no significant interactions between ApoE, HIV infection, and age on cognitive impairment. These data replicate and strengthen prior findings of the lack of association between ApoE ε4 and cognitive outcomes in HIV disease. We conclude that within the specific constraints of an exclusively male study in which the majority of participants were less than 65 years of age (range: 22-87 years), it appears reasonable to conclude that the ε4 allele is not significantly interacting with HIV serostatus.
Url:
DOI: 10.1007/s13365-014-0290-2
PubMed: 25388225
PubMed Central: 4319994
Affiliations:
- États-Unis
- Californie, Pennsylvanie
- Los Angeles, Pittsburgh
- Université de Californie du Sud, Université de Pittsburgh
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Becker</name><affiliation wicri:level="4"><nlm:aff id="A1"> Department of Psychiatry, University of Pittsburgh</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2"> Department of Neurology, University of Pittsburgh</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3"> Department of Psychology, University of Pittsburgh</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Martinson, Jeremy J" sort="Martinson, Jeremy J" uniqKey="Martinson J" first="Jeremy J." last="Martinson">Jeremy J. Martinson</name><affiliation wicri:level="4"><nlm:aff id="A4"> Department of Infectious Diseases and Microbiology, University of Pittsburgh</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Penugonda, Sudhir" sort="Penugonda, Sudhir" uniqKey="Penugonda S" first="Sudhir" last="Penugonda">Sudhir Penugonda</name><affiliation><nlm:aff id="A5"> Division of Infectious Diseases, Department of Medicine</nlm:aff><wicri:noCountry code="subfield">Department of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Kingsley, Lawrence" sort="Kingsley, Lawrence" uniqKey="Kingsley L" first="Lawrence" last="Kingsley">Lawrence Kingsley</name><affiliation wicri:level="4"><nlm:aff id="A4"> Department of Infectious Diseases and Microbiology, University of Pittsburgh</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Molsberry, Samantha" sort="Molsberry, Samantha" uniqKey="Molsberry S" first="Samantha" last="Molsberry">Samantha Molsberry</name><affiliation wicri:level="4"><nlm:aff id="A4"> Department of Infectious Diseases and Microbiology, University of Pittsburgh</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Wolinsky, Steven" sort="Wolinsky, Steven" uniqKey="Wolinsky S" first="Steven" last="Wolinsky">Steven Wolinsky</name><affiliation><nlm:aff id="A5"> Division of Infectious Diseases, Department of Medicine</nlm:aff><wicri:noCountry code="subfield">Department of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Reynolds, Sandra" sort="Reynolds, Sandra" uniqKey="Reynolds S" first="Sandra" last="Reynolds">Sandra Reynolds</name><affiliation><nlm:aff id="A6"> Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health</nlm:aff><wicri:noCountry code="subfield">The Johns Hopkins Bloomberg School of Public Health</wicri:noCountry></affiliation></author><author><name sortKey="Aronow, Aaron" sort="Aronow, Aaron" uniqKey="Aronow A" first="Aaron" last="Aronow">Aaron Aronow</name><affiliation wicri:level="4"><nlm:aff id="A7"> Department of Neurology, University of Southern California</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Goodkin, Karl" sort="Goodkin, Karl" uniqKey="Goodkin K" first="Karl" last="Goodkin">Karl Goodkin</name><affiliation><nlm:aff id="A8"> Department of Mental Health, AIDS Healthcare Foundation (AHF) Los Angeles</nlm:aff><wicri:noCountry code="subfield">AIDS Healthcare Foundation (AHF) Los Angeles</wicri:noCountry></affiliation></author><author><name sortKey="Levine, Andrew" sort="Levine, Andrew" uniqKey="Levine A" first="Andrew" last="Levine">Andrew Levine</name><affiliation><nlm:aff id="A9"> Department of Neurology, University of California Los Angeles</nlm:aff><wicri:noCountry code="subfield">University of California Los Angeles</wicri:noCountry></affiliation></author><author><name sortKey="Martin, Eileen" sort="Martin, Eileen" uniqKey="Martin E" first="Eileen" last="Martin">Eileen Martin</name><affiliation><nlm:aff id="A10"> Department of Psychiatry, Rush University School of Medicine</nlm:aff><wicri:noCountry code="subfield">Rush University School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Miller, Eric N" sort="Miller, Eric N" uniqKey="Miller E" first="Eric N." last="Miller">Eric N. Miller</name><affiliation><nlm:aff id="A11"> Department of Psychiatry, University of California Los Angeles</nlm:aff><wicri:noCountry code="subfield">University of California Los Angeles</wicri:noCountry></affiliation></author><author><name sortKey="Munro, Cynthia A" sort="Munro, Cynthia A" uniqKey="Munro C" first="Cynthia A." last="Munro">Cynthia A. Munro</name><affiliation><nlm:aff id="A12"> Department of Radiology, Northwestern University</nlm:aff><wicri:noCountry code="subfield">Northwestern University</wicri:noCountry></affiliation></author><author><name sortKey="Ragin, Ann" sort="Ragin, Ann" uniqKey="Ragin A" first="Ann" last="Ragin">Ann Ragin</name><affiliation><nlm:aff id="A13"> Department of Psychiatry, The Johns Hopkins University School of Medicine</nlm:aff><wicri:noCountry code="subfield">The Johns Hopkins University School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Sacktor, Ned" sort="Sacktor, Ned" uniqKey="Sacktor N" first="Ned" last="Sacktor">Ned Sacktor</name><affiliation><nlm:aff id="A14"> Neurology, The Johns Hopkins University School of Medicine</nlm:aff><wicri:noCountry code="subfield">The Johns Hopkins University School of Medicine</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of neurovirology</title><idno type="ISSN">1355-0284</idno><idno type="eISSN">1538-2443</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Apolipoprotein E4 (genetics)</term><term>Cognition</term><term>Cognitive Dysfunction (etiology)</term><term>Cognitive Dysfunction (mortality)</term><term>Cognitive Dysfunction (psychology)</term><term>Cognitive Dysfunction (virology)</term><term>Continental Population Groups</term><term>Educational Status</term><term>Gene Expression</term><term>Genotype</term><term>HIV Infections (complications)</term><term>HIV Infections (mortality)</term><term>HIV Infections (psychology)</term><term>HIV Infections (virology)</term><term>Homosexuality, Male</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Prospective Studies</term><term>Survival Analysis</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Allèles</term><term>Analyse de survie</term><term>Apolipoprotéine E4 (génétique)</term><term>Cognition</term><term>Dysfonctionnement cognitif (mortalité)</term><term>Dysfonctionnement cognitif (psychologie)</term><term>Dysfonctionnement cognitif (virologie)</term><term>Dysfonctionnement cognitif (étiologie)</term><term>Expression des gènes</term><term>Facteurs de l'âge</term><term>Génotype</term><term>Homosexualité masculine</term><term>Humains</term><term>Infections à VIH ()</term><term>Infections à VIH (mortalité)</term><term>Infections à VIH (psychologie)</term><term>Infections à VIH (virologie)</term><term>Mâle</term><term>Niveau d'instruction</term><term>Populations d'origine continentale</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests neuropsychologiques</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoprotein E4</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognitive Dysfunction</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Apolipoprotéine E4</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Cognitive Dysfunction</term><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Dysfonctionnement cognitif</term><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Dysfonctionnement cognitif</term><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Cognitive Dysfunction</term><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Dysfonctionnement cognitif</term><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cognitive Dysfunction</term><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Dysfonctionnement cognitif</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Cognition</term><term>Continental Population Groups</term><term>Educational Status</term><term>Gene Expression</term><term>Genotype</term><term>Homosexuality, Male</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Prospective Studies</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Allèles</term><term>Analyse de survie</term><term>Cognition</term><term>Expression des gènes</term><term>Facteurs de l'âge</term><term>Génotype</term><term>Homosexualité masculine</term><term>Humains</term><term>Infections à VIH</term><term>Mâle</term><term>Niveau d'instruction</term><term>Populations d'origine continentale</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests neuropsychologiques</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The ε4 allele of the ApoE gene may have important interactions with physical health and cognitive function among individuals with HIV disease. The purpose of this study is to examine the relationships between ε4, HIV disease, age, neuropsychological impairment and death in a large, well-characterized study sample. 2,846 men participating in the Multicenter AIDS Cohort Study had ApoE genotyping and neuropsychological test data available for analysis. We found a significant association between HIV infection and time to death (from any cause), as well as older age, race, and education. But, ApoE status was not significantly associated with time to death. Similarly, we found a significant association between HIV infection and time to incident cognitive impairment, as well as age, education, and HIV serostatus; Apoε4 status was not related to incident cognitive impairment. There were no significant interactions between ApoE, HIV infection, and age on cognitive impairment. These data replicate and strengthen prior findings of the lack of association between ApoE ε4 and cognitive outcomes in HIV disease. We conclude that within the specific constraints of an exclusively male study in which the majority of participants were less than 65 years of age (range: 22-87 years), it appears reasonable to conclude that the ε4 allele is not significantly interacting with HIV serostatus.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Pennsylvanie</li></region><settlement><li>Los Angeles</li><li>Pittsburgh</li></settlement><orgName><li>Université de Californie du Sud</li><li>Université de Pittsburgh</li></orgName></list><tree><noCountry><name sortKey="Goodkin, Karl" sort="Goodkin, Karl" uniqKey="Goodkin K" first="Karl" last="Goodkin">Karl Goodkin</name><name sortKey="Levine, Andrew" sort="Levine, Andrew" uniqKey="Levine A" first="Andrew" last="Levine">Andrew Levine</name><name sortKey="Martin, Eileen" sort="Martin, Eileen" uniqKey="Martin E" first="Eileen" last="Martin">Eileen Martin</name><name sortKey="Miller, Eric N" sort="Miller, Eric N" uniqKey="Miller E" first="Eric N." last="Miller">Eric N. Miller</name><name sortKey="Munro, Cynthia A" sort="Munro, Cynthia A" uniqKey="Munro C" first="Cynthia A." last="Munro">Cynthia A. Munro</name><name sortKey="Penugonda, Sudhir" sort="Penugonda, Sudhir" uniqKey="Penugonda S" first="Sudhir" last="Penugonda">Sudhir Penugonda</name><name sortKey="Ragin, Ann" sort="Ragin, Ann" uniqKey="Ragin A" first="Ann" last="Ragin">Ann Ragin</name><name sortKey="Reynolds, Sandra" sort="Reynolds, Sandra" uniqKey="Reynolds S" first="Sandra" last="Reynolds">Sandra Reynolds</name><name sortKey="Sacktor, Ned" sort="Sacktor, Ned" uniqKey="Sacktor N" first="Ned" last="Sacktor">Ned Sacktor</name><name sortKey="Wolinsky, Steven" sort="Wolinsky, Steven" uniqKey="Wolinsky S" first="Steven" last="Wolinsky">Steven Wolinsky</name></noCountry><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T." last="Becker">James T. Becker</name></region><name sortKey="Aronow, Aaron" sort="Aronow, Aaron" uniqKey="Aronow A" first="Aaron" last="Aronow">Aaron Aronow</name><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T." last="Becker">James T. Becker</name><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T." last="Becker">James T. Becker</name><name sortKey="Kingsley, Lawrence" sort="Kingsley, Lawrence" uniqKey="Kingsley L" first="Lawrence" last="Kingsley">Lawrence Kingsley</name><name sortKey="Martinson, Jeremy J" sort="Martinson, Jeremy J" uniqKey="Martinson J" first="Jeremy J." last="Martinson">Jeremy J. Martinson</name><name sortKey="Molsberry, Samantha" sort="Molsberry, Samantha" uniqKey="Molsberry S" first="Samantha" last="Molsberry">Samantha Molsberry</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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